Issue Archive
April 2026 | Volume 25 | Issue 4
Editorials
Original Articles
Racial and Ethnic Representation in Clinical Trials of Janus Kinase Inhibitors for Dermatologic Conditions: A Systematic Review
Background: Janus kinase (JAK) inhibitors represent promising therapies for dermatologic conditions, including psoriasis, hidradenitis suppurativa (HS), atopic dermatitis (AD), systemic lupus erythema...
Read MoreExosome-Based Therapies in Dermatology: A Scoping Review
Background: In pre-clinical studies, exosomes activate dermal repair mechanisms, and they may show regenerative potential for skin rejuvenation, pigmentation, scarring, hair loss, and inflammatory der...
Read MoreHydroquinone and Emerging Depigmenting Agents: Clinical Guidelines, Regulatory History, and Global Safety Considerations
Hydroquinone has long served as the gold standard for hyperpigmentation treatment, but safety concerns, regulatory changes, and growing interest in non-hydroquinone therapies have prompted reevaluatio...
Read MoreAn Investigator-Developed Regimen for Treatment and Prevention of Post-Inflammatory Hyperpigmentation in Skin of Color
Background: There is an unmet demand for a post-inflammatory hyperpigmentation (PIH) treatment and prevention that is not only effective and accessible, but also safe to use in darker skin tones. Obj...
Read MoreDiagnostic Accuracy and Pitfalls of Publicly Available Artificial Intelligence Models for Nail Disorders
Background: Artificial intelligence is increasingly applied to dermatology, yet its reliability in clinically high-stakes subspecialty domains such as nail disease remains poorly understood. This stud...
Read MorePatient Interest in Dermatologists in the United States: A 20-Year Google Trends and Workforce Analysis
Background: Dermatologists remain unevenly distributed throughout the United States (US), leading to disparities in access to dermatologic care. Objective: To evaluate geographic variation in patient...
Read MoreObjective Measures Needed: Dermatology Program Directors' Perspectives on the USMLE Step 1 Pass/Fail Transition
Background: Since January 2022, the United States Medical Licensing Examination (USMLE) Step 1 discontinued reporting a 3-digit score. The objective of this study is to share survey results and to com...
Read MoreThe Dermoepidermal Junction as the Initiation Point for Reversal of Dermatoporosis
Background: Dermatoporosis (DP) or chronic cutaneous fragility syndrome has traditionally been linked to extracellular matrix (ECM) dehydration, reduced cellular turnover, epidermal thinning, and vasc...
Read MoreEruptive Lentiginosis Within Resolved Psoriasis Plaques: A Case Report and Systematic Review of the Literature
Background: Many patients with psoriasis suffer from post-inflammatory pigmentary alteration (PIPA), which remains an unmet treatment need. Eruptive lentiginosis (EL) is a rare form of PIPA where mult...
Read MoreRemibrutinib: Insights Into Its Mechanism of Action and Use for Dermatologic Conditions
Objective: Chronic spontaneous urticaria (CSU) is a chronic, debilitating condition characterized by recurrent wheals and/or angioedema. Several cytokines have been linked to CSU, including Bruton tyr...
Read MoreBeyond Efficacy: 0.6% Selenium Disulfide Shampoo Matches 2% Ketoconazole for Seborrheic Dermatitis with Superior Cosmesis
Background: Although most dandruff shampoos are effective, many leave hair dry and unmanageable, potentially impacting patient compliance and treatment outcomes. Objective: This study compared the ef...
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Features
Case Reports
Successful Treatment of Dystrophic Epidermolysis Bullosa With the JAK1 Inhibitor Abrocitinib
Introduction: JAK inhibitors are increasingly being utilized for the treatment of diseases beyond their nonclassical indications, and the highly selective JAK1 inhibitor abrocitinib may represent a p...
Read MoreRapid Clearance of Lichen Planus With Topical Tapinarof
Background: Lichen planus (LP) is an auto-inflammatory idiopathic condition affecting skin, mucous membranes, hair follicles, and nails that presents as pruritic, violaceous papules and plaques. No FD...
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Departments
FULL SUPPLEMENT: Real World Cases of a Novel Topical Tranexamic Acid Serum in Treatment of Hyperpigmentation
Hyperpigmentation and dyschromia are amongst the most common dermatologic concerns for patients seeking care.1 They can affect patients of all skin types and ages, and most commonly occurs after infla...
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Supplements
INDIVIDUAL ARTICLE: Real World Use of Topical Tranexamic Acid Serum in Patients With Hyperpigmentation
Hyperpigmentation and pigmentary alterations are common dermatologic concerns that remain difficult to treat. The modernized topical tranexamic acid serum (TNXA-SHOT) is a novel, patent-pending serum ...
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